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Due to Estraneo Famiglia’s “Possession Bullet”, the entire Famiglia was labelled as brutal and its members were horribly persecuted by the other Mafia Famiglias. Therefore, in order to restore their reputation and power, they decided to create special weapons, which required experiments, which took place on the Famiglia's children; Mukuro was one of those unlucky kids. He disliked the Mafia's treatment toward the Estraneo Famiglia although ironically he also hated the Estraneo as well, for their cruel experiments.

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